Endocrine Abstracts

Introduction: The association of central diabetes insipidus (CDI) and acute myeloid leukaemia is rare. The onset of CDI is variable during the disease course and can be a presenting feature of AMLCase: : A 75 years old Caucasian male patient presented with acute right sided abdominal pain. His initial CT abdomen was normal. He had normocytic anaemia, thrombocytosis and monocytosis. A repeat CT scan 3 days later showed bilateral swollen adrenal glands and...

Pituitary apoplexy caused by pure infarction is rare. Here we present three cases of pituitary macroadenoma infarction following hypotension.1. An 84 year old gentleman had a 2 × 2 cm pituitary macroadenoma causing chiasmal compression and a bitemporal hemianopia. He had panhypopituitarism and was on prednisolone, thyroxine and testosterone replacement. Before surgical intervention of the macroadenoma, he fell and broke his humerus, which requi...

Cabergoline has long been used to treat prolactinomas for symptomatic, radiological and biochemical resolution of pituitary tumours. As clinicians we are well-versed at screening for physical side effects, but are we holistic enough? We present two cases illustrating the damaging social consequences of cabergoline treatment for prolactinomas.Case 1A 49-year-old married father of two presented with a seizure in April 2018. MRI showe...

Menopause management guidelines advocate a personalised, evidence-based approach to menopause-care. This study explored the current landscape of menopause-care, from both patients’ and healthcare-providers’ perspectives, to better understand barriers to menopause-care across the UK.Methods: A 25-question online patient-survey and a 23-question GP-survey was designed with individuals with lived-experience of menopause to underst...

Background: There is emerging evidence that kisspeptin, a hormone with well-established reproductive effects, may also have important metabolic effects. Acute kisspeptin administration enhances insulin secretion under hyperglycaemic conditions in male rodents and men, and kisspeptin receptor agonism improves steatohepatits in male mice in a rodent model of non-alcoholic fatty liver disease. However, the metabolic effects of kisspeptin may exhibit sexual dimorphism as female (b...